Cyclophosphamide acrolein
WebCyclophosphamide (CP) and ifosfamide (IF) are widely used antineoplastic agents, but their side-effect of hemorrhagic cystitis (HC) is still encountered as an important problem. … WebAcrolein is highly corrosive to the skin, the eyes and the respiratory tract, more so than formaldehyde. 1% solutions cause chemical burns. Ocular irritation starts from 0.15–0.25 ppm and one cannot withstand 1 ppm [29]. Inhalation results in ARDS with massive cellular desquamation of the bronchial lining and possibly death [30].
Cyclophosphamide acrolein
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WebA urinary metabolite of cyclophosphamide, acrolein, can cause haemorrhagic cystitis; this is a rare but serious complication that may be prevented by increasing fluid intake for 24–48 hours after intravenous injection. Mesna can also help prevent cystitis when high-dose therapy (e.g. more than 2 g intravenously) is used or when the patient is ... WebSep 29, 2024 · Cyclophosphamide is an alkylating agent that is used in combination with other chemotherapeutic agents for the treatment of a variety of malignant processes. It also has immunosuppressive properties and is increasingly used for the treatment of certain autoimmune diseases, either as a sole agent or in combination with glucocorticoids.
WebAcrolein (systematic name: propenal) is the simplest unsaturated aldehyde. It is a colorless liquid with a piercing, acrid smell. ... Cyclophosphamide and ifosfamide treatment results in the production of acrolein. Acrolein produced during cyclophosphamide treatment collects in the urinary bladder and if untreated can cause hemorrhagic cystitis. WebJul 4, 2024 · Cyclophosphamide is a medication primarily used in the management and treatment of neoplasms, including multiple myeloma, sarcoma, and breast cancer. Cyclophosphamide is a nitrogen mustard …
WebCyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such … WebThis study aims to examine cyclophosphamide (CP) exsposure associated toxicity on rat livers and the likely defensive effects of boric acid (BA). The rats used in this study were divided into four groups: control group, CP group, BA group, and BA + CP group.
WebDec 1, 2014 · Cyclophosphamide, an oxaphosphorine, is a well-known cause of hemorrhagic cystitis. A urinary metabolite of cyclophosphamide, acrolein, is believed to be responsible for hemorrhagic cystitis.1 The best treatment …
WebCyclophosphamide has shown activity as salvage treatment against recurrent PBT in adults and children, used as a single agent or in combination regimens [8,21,75–78 ]. In … screw tetraWebAcrolein, the metabolite of cyclophosphamide and ifosphamide, irritates mucous membranes and is considered pathogenetically important in hemorrhagic cystitis. Increasing fluid intake or administering sodium 2-mercaptoethanesulfonate (mesna), a thiol compound, can reduce the risk of this complication. We measured urinary acrolein concentrations ... screw terminologyWebNational Center for Biotechnology Information payne matthew s mdWebCyclophosphamide is an alkylating agent. It alkylates guanidine nucleotides, thereby blocking cell division. The exact mechanism of cyclophosphamide in vasculitis is poorly understood, but it is thought to have cytotoxic effects on neutrophils and lymphocytes [11] . Cyclophosphamide induces remission in around 90% of patients with AAV [6] screw texture pngWebThe relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide, phosphoramide mustard and nornitrogen mustard, have been studied at pH 4.6 and 7.4. The products formed on alkylation of ethanethiol by these metabolites have screw that gifWebAug 1, 2007 · Cyclophosphamide and ifosfamide are oxazaphosphorines used clinically to treat a wide variety of cancers; however, the role of MGMT in recognizing DNA damage induced by these agents is unclear. In vitro evidence suggests that MGMT may protect against the urotoxic oxazaphosphorine metabolite, acrolein. screw that guyWebCyclophosphamide is a widely used anticancer and immunosuppressive prodrug that unfortunately causes severe adverse effects, including cardiotoxicity. Although the exact cardiotoxic mechanisms are not completely understood, a link between cyclophosphamide's pharmacologically active metabolites, name … screw testing